Oxford Biomedica signs new licence agreement with US biotech Arcellx

Oxford Biomedica

Oxford Biomedica, the leading gene and cell therapy group, has signed a new Licence and Supply Agreement with North American company Arcellx Inc.

Arcellx is a biotechnology company developing novel, adaptive and controllable cell therapies for the treatment of patients with cancer and autoimmune diseases. The agreement grants Arcellx a non-exclusive licence to Oxford Biomedica’s LentiVector® platform for its application in select Arcellx CAR-T programmes and puts in place a three-year Clinical Supply Agreement.

Under the terms of the LSA, Oxford Biomedica will receive payments related to the development and manufacturing of lentiviral vectors for use in clinical trials. Additionally, the agreement allows for payments to the Group for the manufacture and supply of lentiviral vectors for commercial use.

This partnership builds on the longstanding partnerships with Novartis and Bristol Myers Squibb, as well as the more recently announced partnership with Beam Therapeutics.

John Dawson, Chief Executive Officer of Oxford Biomedica, said: “Arcellx is one of the leading next-generation CAR-T developers deploying a wide range of innovative technologies to bring innovative CAR-T products into development. We are proud to be working with a leader in the field of CAR-T that shares our vision of delivering cell and gene therapies to save lives. This is yet another valuable opportunity for our LentiVector® platform to support innovative product development of CAR-T products further highlighting Oxford Biomedica’s position as a partner of choice.”

Rami Elghandour, Chairman and CEO of Arcellx said: “We look forward to leveraging Oxford Biomedica’s renowned LentiVector® platform technology, and their industry-leading development and GMP manufacturing expertise in the clinical and commercial development of our CAR-T programmes.”

In September, Oxford Biomedica – which has been manufacturing the Oxford AstraZeneca vaccine throughout the year, revealed that revenues had increased by a record 139 per cent to £81.3 million this year.

It also announced that Serum Life Sciences Ltd,a subsidiary company of Serum Institute of India Pvt Ltd had agreed to invest just over £50 million in the Group.

The investment will be used to fund the development of the fallow area at Oxbox, the Group’s 84,000 sq. ft manufacturing facility based in Oxford, UK, into a flexible advanced manufacturing space and the validation of several independent cGMP suites, expected to come online in mid-2023. (cGMP refers to the Current Good Manufacturing Practice).